國立陽明大學傳統醫藥學研究所博士

哈佛大學醫學院暨麻省眼耳醫院 訪問學者(2024/8)
馬偕醫學院 生物醫學研究所 專任副教授 (2019/2-2022/1)
馬偕醫學院生物醫學研究所 專任助理教授(2013/2-2019/1)

國家衛生研究院 細胞及系統醫學研究所 助理研究學者(2012/8-2013/1)
國家衛生研究院 細胞及系統醫學研究所 博士後研究員(2008/1-2012/7)
國家衛生研究院 幹細胞研究中心 博士後研究員 (2006/1-2008/1)

馬偕醫學院 聽力暨語言治療學系 專任教授兼系主任 (2022/2-迄今)
馬偕醫學院 生物醫學研究所 合聘教授 (2022/2-迄今)

1. 聽語疾病之機轉與生物醫學研究
2. 再生醫學於聽能創復健之未來應用
3. 幹細胞生物學
4. 分子細胞生物學/基因調控學

1. 聽語疾病之機轉與治療研究(藥物、基因與細胞治療)
2. 神經相關疾病之機轉研究
3. 幹細胞生長與分化調控研究
4. 體細胞核重組(Nuclear Reprogramming)與人類誘導型多功能幹細胞(iPSCs)之研究與應用

1. Wu YT, Huang SC, Shiao YM, Syc WC, Wei YH, Hsu YC*.  Identification of new variants in MTRNR1 and MTRNR2 genes using whole mitochondrial genome sequencing in a Taiwanese family with MERRF (myoclonic epilepsy with ragged-red fibers) syndrome. HEARING RESEARCH. Vol.438:e108876. Oct. 2023. (SCI/SCIE) ( SDGs3, SDGs9)
2. Chen CP, Chen PC, PAN YL, HSU YC*.  Prenatal lipopolysaccharide exposure induces anxiety-like behaviour in male mouse offspring and aberrant glial differentiation of embryonic neural stem cells. CELLULAR & MOLECULAR BIOLOGY LETTERS. Vol.28-No.1:e67. Aug. 2023. (SCI/SCIE) ( SDGs3)
3. Chou CW, Hsu YC*.  Current development of patient-specific induced pluripotent stem cells harbouring mitochondrial gene mutations and their applications in the treatment of sensorineural hearing loss. HEARING RESEARCH. Vol.429:e108689. Mar. 2023. (SCI/SCIE)
4. Dian-Shiue Lee, Yu-Ling Pan, Yi-Chao Hsu*.  Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage. Jove-Journal of Visualized Experiments. Vol.192:e64286. Feb. 2023. (SCI/SCIE) ( SDGs3)
5. Kuang-Hsi Chang, Chieh-Lin Jerry Teng, Yi-Chao Hsu, Stella Chin-Shaw Tsai, Han-Jie Lin, Tsai-Ling Hsieh, Chih-Hsin Muo, Chung Y. Hsu, Ruey-Hwang Chou.  Long-Term Exposure to Air Pollution Associates the Risk of Benign Brain Tumor: A Nationwide, Population-Based, Cohort Study in Taiwan. Toxics. Vol.10-No.4:e176. Apr. 2022. (SCI/SCIE)
6. Tsai CS, Lin CF, Chang KH, Li MC, Chou RH, Huang MY, Chen YC, Kao CY, Cheng CC, Lin HC, Hsu YC*.  The intravenous administration of skin-derived mesenchymal stem cells ameliorates hearing loss and preserves cochlear hair cells in cisplatin-injected mice. HEARING RESEARCH. Vol.413:e108254. Jan. 2022. (SCI/SCIE)
7. Lin YF , Lin HC , Tsai CL , Hsu YC*.  GJB2 Mutation Spectrum in the Taiwanese Population and Genotype–Phenotype Comparisons in Patients with Hearing Loss Carrying GJB2 c.109G>A and c.235delC Mutations. HEARING RESEARCH. Vol.413:e108135. Jan. 2022. (SCI/SCIE)
8. Han-Jie Lin, Stella Chin-Shaw Tsai, Frank Cheau-Feng Lin, Yi-Chao Hsu, Shih-Wei Chen, Ruey-Hwang Chou, Cheng-Li Lin, Chung Y. Hsu, Kuang-Hsi Chang.  Prolonged Exposure to Air Pollution Increases Periodontal Disease Risk: A Nationwide, Population-Based, Cohort Study. Atmosphere. Vol.12-No.12:e1688. Dec. 2021. (SCI/SCIE)
9. Hsu YC, Chung YF, Chen MS, Wang CK, Jiang ST, Chiu IM..  Establishing F1A-CreER T2 Mice to Trace Fgf1 Expression in Adult Mouse Cardiomyocytes. Cells. Vol.11-No.1:e121. Dec. 2021. (SCI/SCIE)
10. Tsai SC#, Hsu YC#, Lai JN, Chou RH, Fan HC, Lin FC, Zhang R, Lin CL, Chang KH.  Long-term exposure to air pollution and the risk of developing sudden sensorineural hearing loss. Journal of Translational Medicine. Vol.19-No.1:e424. Oct. 2021. (SCI/SCIE)
11. Hung-Lin Chen, Ruihong Zhang, Stella Chin-Shaw Tsai, Ruey-Hwang Chou, Yi-Chao Hsu, Hueng-Chuen Fan, Chih-Hsin Muo, Chung Y. Hsu, Kuang-Hsi Chang.  Ambient Air Pollution Exposure and Risk of Developmental Delay in Children and Teenagers in Taiwan. Atmosphere. Vol.12(8):e1039. Aug. 2021. (SCI/SCIE)
12. Tsai SC, Yang KD, Chang KH, Lin FC, Chou RH, Li MC, Cheng CC, Kao CY, Chen CP, Lin HC, Hsu YC*.  Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Vol.22(13):e6664. Jun. 2021. (SCI/SCIE)
13. Lu HE, Pan YL, Ko HW, Hsu SH, Wen CH, Hsu YC*.  Generation of induced pluripotent stem cells FIRDIi001-A from a Taiwanese subject carrying ALDH2 pE487K mutation. Stem Cell Research. Vol.52:e102229. Apr. 2021. (SCI/SCIE)
14. Chong LW, Tsai CL, Yang KC, Liao CC, Hsu YC*.  Targeting protein palmitoylation decreases palmitate-induced sphere formation of human liver cancer cells. Molecular Medicine Reports. Vol.22-No.2:939-947. Aug. 2020. (SCI/SCIE)
15. Chang KH, Hsu YC, Chiu IM, Chen LC, Hsu CC, Lee CY, Fan HC, Chen HJ, Chou RH.  Association between periodontitis and bipolar disorder: A nationwide cohort study. MEDICINE. Vol.99:21423-21423. Jul. 2020. (SCI/SCIE)
16. Chen HL, Hsu YC, Chen CH, Wang PJ, Lin CL, Cheng SH, Chang KH.  Gout and the risk of epilepsy: A population-based cohort study.. MEDICINE. Vol.99:20823-20823. Jun. 2020. (SCI/SCIE)
17. Chang KH, Tsai SC, Lee CY, Chou RH, Fan HC, Lin FC, Lin CL, Hsu YC*.  Increased Risk of Sensorineural Hearing Loss as a Result of Exposure to Air Pollution. International Journal of Environmental Research and Public Health. Vol.17:1-13. Mar. 2020. (其他具同儕審查機制之期刊)
18. Lu HE, Tsai CL, Chiu IM, Pan YL, Lin YF, Lin HC, Hsu YC*.  Generation of induced pluripotent stem cells MMCi001-A from a Taiwanese hearing loss patient carrying GJB2 pV37I mutation.. Stem Cell Research. Vol.42:1-5. Jan. 2020. (SCI/SCIE)
19. Fan HC, Chen CY, Hsu YC, Chou RH, Teng CJ, Chiu CH, Hsu CY, Muo CH, Chang MY, Chang KH.  Increased risk of incident nasopharyngeal carcinoma with exposure to air pollution. PLoS One. Vol.13:e0204568-e0204568. Sep. 2018. (SCI/SCIE)
20. Chou RH, Lee CY, Chong LW, Chang KH, Lin CL, Yan KS, Tsou C, Hsu YC*.  HBV infection increases the risk of macular degeneration: the roles of HBx-mediated sensitization of retinal pigment epithelial cells to UV and blue light irradiation. Journal of Translational Medicine. Vol.16:221-236. Aug. 2018. (SCI/SCIE)
21. Chong LW, Hsu CC, Lee CY, Chou RH, Lin CL, Chang KH, Hsu YC*.  Association of viral hepatitis and bipolar disorder: a nationwide population-based study. Journal of Translational Medicine. Vol.16(1):e173-e183. Jun. 2018. (SCI/SCIE)
22. Chen YC, Tsai CL, Wei YH, Wu YT, Hsu WT, Lin HC, Hsu YC*.  ATOH1/RFX1/RFX3 transcription factors facilitate the differentiation and characterisation of inner ear hair cell-like cells from patient-specific induced pluripotent stem cells harbouring A8344G mutation of mitochondrial DNA. Cell Death & Disease. Vol.9:437-440. Apr. 2018. (SCI/SCIE)
23. Hsu YC, Wu YT, Tsai CL, Wei YH.  Current understanding and future perspectives of the roles of sirtuins in the reprogramming and differentiation of pluripotent stem cells. EXPERIMENTAL BIOLOGY AND MEDICINE. Vol.243(6):563-575. Mar. 2018. (SCI/SCIE)
24. Wu YT, Hsu YH, Huang CY, Ho MC, Cheng YC, Wen CH, Ko HW, Lu HE, Chen YC, Tsai CL, Hsu YC*, Wei YH, Hsieh PCH.  Generation of an induced pluripotent stem cell (iPSC) line from a 40-year-old patient with the A8344G mutation of mitochondrial DNA and MERRF (myoclonic epilepsy with ragged red fibers) syndrome. Stem Cell Research. Vol.27:10-14. Mar. 2018. (SCI/SCIE)
25. Hsu YH, Wu YT, Huang CY, Ho MC, Cheng YC, Syu SH, Lu HE, Chen YC, Tsai CL, Lin HC, Wei YH*, Hsu YC*, Hsieh PCH.  Generation of an induced pluripotent stem cell line from a 39-year-old female patient with severe-to-profound non-syndromic sensorineural hearing loss and a A1555G mutation in the mitochondrial MTRNR1 gene. Stem Cell Research. Vol.25:245-249. Dec. 2017. (SCI/SCIE)
26. Su PJ, Hsu CC, Lin HC, Huang WS, Yang TL, Hsu WT, Lin CL, Hsu CY, Chang KH*, Hsu YC*.  Age-related hearing loss and dementia: a 10-year national population-based study.. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. Vol.274:2327-2334. May. 2017. (SCI/SCIE)
27. Chang KH*, Hsu YC, Hsu WT, Hsu CC, Wen MH, Lin HC, Tsai HT, Su P, Sun CT, Lin CL, Hsu CY*.  Increased risk of depression in patients with acquired sensory hearing loss: A 12-year follow-up study. MEDICINE. Vol.95:5312-5319. Nov. 2016. (SCI/SCIE)
28. Chang KH, Hsu CC, Muo CH, Hsu CY, Liu HC, Kao CH, Chen CY,, Chang MY, Hsu YC*.  Air pollution exposure increases the risk of rheumatoid arthritis: A longitudinal and nationwide study. Environment International. Vol.94:495-499. Sep. 2016. (SCI/SCIE)
29. Hsu CC, Hsu YC, Chang KH, Lee CY, Chong LW, Lin CL, Kao CH.  Association of Dementia and Peptic Ulcer Disease: A Nationwide Population-Based Study. American Journal of Alzheimer's Disease & Other Dementias. Vol.31:389-394. Aug. 2016. (SCI)
30. Hsu YC, Kao CY, Chung YF, Lee DC, Liu JW, Chiu IM.  Activation of Aurora A kinase through the FGF1/FGFR signaling axis sustains the stem cell characteristics of glioblastoma cells. EXPERIMENTAL CELL RESEARCH. Vol.344:153-166. Jun. 2016. (SCI/SCIE)
31. Hsu CC, Hsu YC, Chang KH, Lee CY, Chong LW, Wang YC, Hsu CY, Kao CH.  Increased risk of fracture in patients with bipolar disorder: a nationwide cohort study. SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY. Vol.51:1331-1338. May. 2016. (SSCI)
32. Hsu YC, Wu YT, Yu TH, Wei YH.  Mitochondria in mesenchymal stem cell biology and cell therapy: from cellular differentiation to mitochondrial transfer. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. Vol.52:119-131. Apr. 2016. (SCI/SCIE)
33. Chang KH, Hsu YC, Hsu CC, Lin CL, Hsu CY, Lee CY, Chong LW, Liu HC, Lin MC, Kao CH.  Prolong Exposure of NSAID in Patients With RA Will Decrease the Risk of Dementia: A Nationwide Population-Based Cohort Study. MEDICINE. Vol.95:e3056-e3056. Mar. 2016. (SCI/SCIE)
34. Hsu CC, Hsu YC, Chang KH, Lee CY, Chong LW, Lin CL, Shang CS, Sung FC, Kao CH.  Depression and the Risk of Peptic Ulcer Disease: A Nationwide Population-Based Study. MEDICINE. Vol.94:2333-2333. Dec. 2015. (SCI/SCIE)
35. Hsu CC, Hsu YC, Chen HJ, Lin CC, Chang KH, Lee CY, Chong LW, Kao CH.  Association of Periodontitis and Subsequent Depression: A Nationwide Population-Based Study. MEDICINE. Vol.94:2347-2347. Dec. 2015. (SCI/SCIE)
36. Chang KH, Hsu YC, Chang MY, Lin CL, Wu TN, Hwang BF, Chen CY, Liu HC, Kao CH.  A Large-Scale Study Indicates Increase in the Risk of Epilepsy in Patients With Different Risk Factors, Including Rheumatoid Arthritis. MEDICINE. Vol.94:e1485-e1485. Sep. 2015. (SCI/SCIE)
37. Hsu YC, Hsu CC, Chang KH, Lee CY, Chong LW, Wang YC, Kao CH.  Increased Subsequent Risk of Peptic Ulcer Diseases in Patients With Bipolar Disorders. MEDICINE. Vol.94:1203-1203. Jul. 2015. (SCI/SCIE)
38. Chong LW, Hsu YC, Lee TF, Lin Y, Chiu YT, Yang KC, Wu JC, Huang YT.  Fluvastatin attenuates hepatic steatosis-induced fibrogenesis in rats through inhibiting paracrine effect of hepatocyte on hepatic stellate cells. BMC Gastroenterology. Vol.15:e22. Feb. 2015. (SCI/SCIE)
39. Hsu YC, Chen SL, Wang YJ, Chen YH, Wang DY, Chen L, Chen CH, Chiu IM.  Signaling adaptor protein SH2B1 enhances neurite outgrowth and accelerates the maturation of human induced neurons. Stem Cells Translational Medicine. Vol.3-No.6:713-722. Jun. 2014. (SCI/SCIE)
40. Kao CY #, Hsu YC #, Liu JW, Lee DC, Chung YF, Chiu IM.  The mood stabilizer valproate activates human FGF1 gene promoter through inhibiting HDAC and GSK-3 activities. JOURNAL OF NEUROCHEMISTRY. Vol.126-No.1:4-18. Jul. 2013. (SCI/SCIE)
41. Liu JW, Hsu YC, Kao CY , Su HL, Chiu IM.  LIF-induced Stat3 signaling suppresses FGF1-induced Erk1/2 activation to inhibit the downstream differentiation in mouse embryonic stem cells. STEM CELLS AND DEVELOPMENT. Vol.22-No.8:1190-1197. Apr. 2013. (SCI/SCIE)
42. Hsu YC, Kao CY, Chung YF, Chen MS, Chiu IM.  Ciliogenic RFX transcription factors regulate FGF1 gene promoter. JOURNAL OF CELLULAR BIOCHEMISTRY. Vol.113-No.7:2511-2522. Jul. 2012. (SCI/SCIE)

1. Yi-Chao Hsu*.  Implantation of neural progenitor cells derived from human induced pluripotent stem cells improves sensorineural hearing loss in mouse model. 2023 Initernational Symposium for Inner Ear Therapeutics (Session Chair and Invited Speech). Apr. 2023.
2. Yi-Chao Hsu*.  Applications of Stem Cell-Based Therapies in the Treatment of Sensorineural Hearing Loss. Cell & Gene Therapy Research & Development Congress Asia 2023 (Invited Speech). Mar. 2023.
3. Yi-Chao Hsu*。  Stem Cell-based therapeutic approaches for sensorineural hearing loss. The 36th Joint Annual Meeting Conference of Biomedical Sciences (Invited Speech, 生物醫學聯合年會解剖學會). 3月 2022.
4. Yi-Chao Hsu*.  Stem Cells and Stem Cell-Derived Molecules for the Treatment of Hearing Loss. 44th Annual ARO MidWinter Meeting (Invited Speaker, 國際耳鼻喉科年會，美國，佛羅里達). Feb. 2021.
5. Yi-Chao Hsu*.  Stem cell-based therapies for sensorineural hearing loss. 2020 International Conference on Stem Cell & Gene Therapy; (Invited Speaker, 台灣幹細胞年會). Oct. 2020.
6. Yi-Chao Hsu*.  Application of Stem Cells and Extracellular Vesicles in the Treatment of Hearing Loss. 2019 International Symposium of Inner Ear Therapy (Session Chair and Invited Speech 德國，漢諾威). Nov. 2019.
7. Yi-Chao Hsu*.  Elevated Levels of ROS and Antioxidant Gene Expression in Inner Ear Hair Cell-like Cells Differentiated from Human Induced Pluripotent Stem Cells with mtDNA Mutation. 2018 Asia Society for Mitochondrial Research and Medicine (Invited Speaker 韓國、釜山). Nov. 2018.
8. Yi-Chao Hsu*.  Elevated Levels of ROS and Antioxidant Gene Expression in Inner Ear Hair Cell-like Cells Differentiated from Human Induced Pluripotent Stem Cells with mtDNA Mutation. 2018 Annual Meeting of Taiwan Society for Stem Cell Research (Invited Speaker, 台灣幹細胞年會). Oct. 2018.
9. Yi-Chao Hsu.  Research and application of stem cells in the regeneration of inner ear hair cells. 2018 Research of Ear and Hearing (Invited Speaker, Taipei Veteran Hospital 台北榮民總醫院). Aug. 2018.
10. Yi-Chao Hsu*.  Characterization of Molecular and Stereociliary Structural Changes in Hair-Cell-like-Cells from Human Induced Pluripotent Stem Cells of Patients with Mitochondrial DNA A8344G Mutation. The first International symposium on Inner Ear Therapies (Selected Oral Presentation)(摩洛哥，馬拉喀什). Nov. 2017.
11. Yi-Chao Hsu.  Elevated Levels of ROS and Antioxidant Gene Expression in Inner Ear Hair Cell-like Cells Differentiated from Human Induced Pluripotent Stem Cells with mtDNA Mutation. 2017國際幹細胞研究年會 (美國、波士頓). Jun. 2017.
12. Yi-Chao Hsu.  Stem Cells and the impact of ROS signaling. International Symposium on Redox Biology and Mitochondrial Medicine (Selected Oral Presentation). Oct. 2016.
13. Yi-Chao Hsu.  Activation of Aurora A Kinase through the FGF1/FGFR signaling axis sustainsthe stem cell characteristics of glioblastoma cells. 2016 國際幹細胞研究年會(美國，舊金山). Jun. 2016.
14. Yi-Chao Hsu.  Cellular Reprogramming Approaches for the Generation of Human Induced Neurons and Inner Ear Hair Cells. EITA-Bio 2015 (Invited Speech). Oct. 2015.
15. Yi-Chao Hsu.  Activation of Aurora-A kinase through FGF1/FGFR signaling axis sustains the neural stem cell characteristics of glioblastoma cells. 2015 國際幹細胞研究年會 (瑞典，斯德哥爾摩). Jun. 2015.
16. Yi-Chao Hsu.  The mood stabilizer valproate activates human FGF1 gene promoter through inhibiting HDAC and GSK3 activities. 2014 國際幹細胞研究年會 (加拿大，溫哥華). Jun. 2014.
17. Yi-Chao Hsu.  FGF1-dependent Aurora-A Kinase Activity Sustains the Self-Renewal and Multipotency of Neural Stem Cells and Glioblastoma Stem Cells. 2013 國際幹細胞研究年會 (美國，波士頓). Jun. 2013.

hsuyc@mmc.edu.tw